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Time-course of reprogramming mouse fibroblasts into induced pluripotent stem cells

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Time-course of reprogramming mouse fibroblasts into induced pluripotent stem cells:

Fibroblasts were transduced with the four reprogramming factors Oct4, Sox2, Klf4 and c-Myc and cultured in mouse embryonic stem cell culture media.  Within 12 days post-transduction the morphology of the fibroblasts changed considerably and by the 12th day distinct iPS colonies readily formed. Image courtesy of Harvard Stem Cell Institute.
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