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Role of cooperativity of binding in regulation

Description
Role of cooperativity of binding in regulation. The activity of an allosteric enzyme with a sigmoidal binding curve can be altered markedly when either an activator or an inhibitor is bound to the enzyme. Addition of an activator can lower the apparent Km raising the activity at a given . Conversely, addition of an inhibitor can raise the apparent Km producing less activity at a given .
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