Top Posters
Since Sunday
g
3
3
2
J
2
p
2
m
2
h
2
s
2
r
2
d
2
l
2
a
2
SlideshowReport

Androgens modulate the inflammatory response during acute wound healing

Description
Proposed mechanism for the androgenic regulation of wound healing. DHT binds to the AR and the resulting ligand-activated AR represents an effector complex whose activities may be modulated by Smad3. Activated AR stimulates macrophage production of pro-inflammatory cytokines, while at the same time depressing fibroblast cytokine expression and secretion. The increase in macrophage cytokine release, which depends on MAPK and PI 3-kinase signalling, contributes to enhanced inflammation and hence delayed healing.
Related Images
Add Comment
Explore
Post your homework questions and get free online help from our incredible volunteers
  1121 People Browsing
 113 Signed Up Today
Your Opinion
Who will win the 2024 president election?
Votes: 3
Closes: November 4