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Sherri044
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Dec 15, 2011

. Jim Fitch decided that his physique left much to be desired, so he joined a local health club and began to "pump iron" three times weekly. After three months of training, during which he was able to lift increasingly heavier weights, he noticed that his arm and chest muscles were substantially larger. Explain the structural and functional basis of these changes.

2. When a suicide victim was found, the coroner was unable to remove the drug vial clutched in his hand. Explain the reasons for this. If the victim had been discovered three days later, would the coroner have had the same difficulty? Explain.

3. Muscle-relaxing drugs are administered to a patient during major surgery. Which of the two chemicals described next would be a good skeletal muscle relaxantand why?
-Chemical A binds to and blocks ACh receptors of muscle cells
-Chemical B floods the muscle cells' cytoplasm with Ca(2+)

4. Michael is answering a series of questions dealing with skeletal muscle cell excitation and contraction. In response to "What protein changes shape with Ca(2+) binds to it?" he writes "tropomyosin." What should he have responded and what is the result of that calcium ion bonding?


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Dec 15, 2011

2. When a suicide victim was found, the coroner was unable to remove the drug vial clutched in his hand. Explain the reasons for this. If the victim had been discovered three days later, would the coroner have had the same difficulty? Explain.

When an organism dies, its muscles remain in a contracted state termed "rigor mortis" for a brief period of time. The anatomical reason why this happens is because ATP is no longer available to break bonds between the thick and thin filaments, which allows the natural movement of muscle tissue.



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Dec 15, 2011

2. When a suicide victim was found, the coroner was unable to remove the drug vial clutched in his hand. Explain the reasons for this. If the victim had been discovered three days later, would the coroner have had the same difficulty? Explain.

When an organism dies, its muscles remain in a contracted state termed "rigor mortis" for a brief period of time. The anatomical reason why this happens is because ATP is no longer available to break bonds between the thick and thin filaments, which allows the natural movement of muscle tissue.

Rigor mortis( stiff, rigid muscles in temp state of total contraction, aka, tetany, aka stiff as a board) after death involves the release of Ca2+ ions from the SR once the active transport has stopped actively producing ATP. Once the proteins breakdown, (due to no blood flow, 02, electrolyte changes, etc) contraction stops. There are however phases of rigor mortis, early onset most acute, but there is a stage afterward, 72hrs, that it still exists. look this up for more info, but as a med student having worked on cadavers, i can tell you, they don't move like gumby.  Smile



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Dec 15, 2011

Rigor mortis! You have to look up the details, but it's basically because ATP isn't produced and the myosin head cannot detach from actin. Rigor mortis is past its peak after three days. So no, the coroner wouldn't have as much difficulty.



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