× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
g
3
3
2
J
2
p
2
m
2
h
2
s
2
r
2
d
2
l
2
a
2
New Topic  
ppk ppk
wrote...
Valued Member
On Hiatus
Posts: 3561
13 years ago
Suppose you were to carry out a mosaic analysis of the EGFR homolog let-23, using a homozygous let-23(-) strain that carries a small free duplication including the let-23(+) gene.  The duplication is occasionally lost during somatic development, producing a mosaic animal. The vulval precursor cells are derived from the AB lineage, while the entire gonad is derived from the P1 lineage. What phenotype, Vul or normal, would you predict if the duplication were lost in P1 but retained in AB?  If it were lost in AB but retained in P1?  How is this gene product behaving—in a cell autonomous or non-autonomous fashion?
Read 1653 times
1 Reply

Related Topics

Replies
wrote...
Educator
13 years ago
Making the vulva requires that a lin-3 encoded signal from the gonadal anchor cell is sensed by a let-23- encoded receptor on the VPC P6p.  The gonad is derived from P1; the VPCs from AB. Therefore, vulva formation will work fine without let-23 expression in the AC (ie, normal when let-23 is lost in P1), but will require let-23 in the VPCs (thus Vul when le23 lost in AB lineage that makes the VPCs).  It’s autonomous—it’s a receptor. 
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  1039 People Browsing
 125 Signed Up Today
Related Images
  
 250
  
 497
  
 931
Your Opinion
Which industry do you think artificial intelligence (AI) will impact the most?
Votes: 352

Previous poll results: What's your favorite math subject?