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Home Q & A Board Biology-Related Homework Help Biochemistry
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tnfalpha tnfalpha
wrote...
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9 years ago
I would like to know whether the TNF alpha gets phosphorylated prior binding to its receptor, if so, then I would also like to know the rate constant of this reaction (not the binding to the receptor rate constant, but phosphorylation rate constant). Does anyone knows something about this, please?
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wrote...
#1
Educator
9 years ago
I think your question is missing information. What biochemical pathway are we talking about?
wrote...
#2
9 years ago
Sorry, to not to be clear.

My question was, that does the trimeric form of soluble TNF alpha prior binding to its receptor get phosphorylated? Or once it formed the trimers can bind the TNFR1 without any further post-translational modification. And I was curious about the rate constant of this possible phosphorylation reaction, which I know depends on concentration, temperature etc. but any approximate information on given conditions would help already.


Thank you for your reaction!
wrote...
#3
Educator
9 years ago
https://biology-forums.com/index.php?action=gallery;sa=view;id=18840

I believe phosphorylation brings the TNF factor together with the trimer.
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