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PhysioEx 8.0 exercise 4 endocrine system physiology
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I cannot figure out activity 1 # 12, activity 4 # 7 activity 8 # 17

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Reply# 1
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4 years ago

I cannot figure out activity 1 # 12, activity 4 # 7 activity 8 # 17

Don't have 1. #12

Activity 4: Determining the Effect of Propylthiouracil
on Metabolic Rate (p. 48)
7. On the normal rat, the metabolic rate after propylthiouracil injection is slower than the
baseline metabolic rate.
Propylthiouracil is antagonistic to thyroxine and will tend to decrease the effects of
thyroxine.
On the thyroidectomized rat, the metabolic rate after propylthiouracil injection is the
same as the baseline metabolic rate.
Since the thyroidectomized rat cannot make any thyroxine, the propylthiouracil has
nothing to be antagonistic to and therefore has no effect.
On the hypophysectomized rat, the metabolic rate after propylthiouracil injection is the
same as the baseline metabolic rate.
Since the hypophysectomized rat does not have a functional thyroid gland, no thyroxine
is being made and there is nothing for the propylthiouracil to be antagonistic to.

Activity 8: Measuring Cortisol and Adrenocorticotropic Hormone (pp. 55–57)
17. Patient 1: cortisol 3 ± 1 mcg/dL Low ACTH 18 ± 2 pg/ml Low
Patient 2: cortisol 35 ± 5 mcg/dL High ACTH 13 ± 2 pg/ml Low
Patient 3: cortisol 45 ± 5 mcg/dL High ACTH 86 ± 5 pg/ml High
Patient 4: cortisol 3 ± 1 mcg/dL Low ACTH 100 ± 5 pg/ml High
Patient 5: cortisol 50 ± 5 mcg/dL High ACTH 18 ± 2 pg/ml Low

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Reply# 2
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4 years ago

This is probably a bit late but Activity 1 #12 is not given in duddy's answer key because you have to use data that you have collected and recorded in chart 1. After you convert the weight data from grams to kilograms use the formula given to determine the metabolic rate. These answers will vary depending on what you have on your chart.



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4 years ago

Activity 1 #12
Your answers go written on the chart
BASELINE
normal rat: 1741.1 ml O2/kg./Hr
Thyroidectomized Rat: 1496.9 ml O2/Kg./Hr
Hypophysectomized Rat: 1489.0 ml O2/Kg./Hr

Answers may vary though. Those are just some of mine



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4 years ago

Activity 1 #12 - 1678.7 ml O2/kg/hr



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4 years ago

normal rat: 1741.1 ml O2/kg./Hr
Thyroidectomized Rat: 1496.9 ml O2/Kg./Hr
Hypophysectomized Rat: 1489.0 ml O2/Kg./Hr



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3 years ago

Activity 8:  Measuring Cortisol and Adrenocorticotropic Hormone - This is broke down for you but it is all of Question 17.

1.   Patient 1: Cortisol:   2.86  mcg/dL
2.   High or Low? low
3.   Patient 1: ACTH:    18.40       pg/ml
4.   High or Low? low
5.   Patient 2: Cortisol:    32.25     mcg/dL
6.   High or Low? high
7.   Patient : ACTH:    11.72         pg/ml
8.   High or Low? low
9.   Patient 3: Cortisol:    41.94     mcg/dL
10.   High or Low? high
11.   Patient 3: ACTH:  90.43        pg/ml
12.   High or Low? high
13.   Patient 4: Cortisol:  3.99       mcg/dL
14.   High or Low? low
15.   Patient 4: ACTH:     95.38      pg/ml
16.   High or Low? high
17.   Patient 5: Cortisol:    52.93     mcg/dL
18.   High or Low? high
19.   Patient 5: ACTH:     18.37      pg/ml
20.   High or Low? low



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3 years ago

Exercise 4: Activity 4:  Determining the Effect of Propylthiouracil on Metabolic Rate

1.   What was the effect of propylthiouracil on the normal rat’s metabolic rate?  It caused the rate to decrease. How does it compare to the normal rat’s baseline metabolic rate?  The metabolic rate of the baseline rat was significantly higher
2.   Why was this effect seen? Injected with tyroxine caused an increase in grams and ml of O2 levels, because the tyroxine is a hormone from tyroid gland which increase the basal metabolic rate.
3.   What was the effect of propylthiouracil on the thyroidectomized rat’s metabolic rate?  There was no effect. How does it compare to the thyroidectomized rat’s baseline metabolic rate?  The metabolic rate was the same for the two (2) rats.
4.   Why was this effect seen?  The rat needs both the pituitary glands as well as the thyroid gland to produce thyroxine. PTU inhibits the production of the thyroxine, but thyroxine is already not being produced in this rat due to the absence of the pituitary and/or thyroid glands.
5.   What was the effect of propylthiouracil on the hypophysectomized rat’s metabolic rate?  There was no effect. How does it compare to the hypophysectomized rat’s baseline metabolic rate?   The metabolic rate of the baseline rat was the same for these two (2) rats.
6.   Why was this effect seen?  Because propylthiouracil is an anti-thyroid drug used to treat hyperthyroidism by decreasing the amount of hormone produced by the thyroid gland and the rat had the thyroid gland removed.



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