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Home Q & A Board Biology-Related Homework Help Anatomy and Physiology
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ehd123 ehd123
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Posts: 778
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9 years ago
Could someone please explain the difference between patch clamp and voltage clamp techniques used in neuroscience studies?

Many thanks
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2 Replies
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience

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wrote...
#1
9 years ago
Unlike traditional two-electrode voltage clamp recordings, patch clamp recording uses a single electrode to record currents. Many patch clamp amplifiers do not use true voltage clamp circuitry but instead are differential amplifiers that use the bath electrode to set the zero current level. This allows a researcher to keep the voltage constant while observing changes in current. Alternatively, the cell can be current clamped in whole-cell mode, keeping current constant while observing changes in membrane voltage.

[Animation] - The Patch Clamp Method
ehd123 Author
wrote...
#2
Valued Member
9 years ago
Thank you so much =)
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience
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