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Explain the principle difference between direct agglutination and passive agglutination.
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Direct agglutination is clumping formed from soluble antibodies binding to soluble antigens that are either bound to the surface of a cell or bound to an insoluble particle. Passive agglutination again uses soluble antibodies, but the antigens of interest are also soluble, so they are first adsorbed to an inert antigen-carrier such as charcoal particles, latex beads, or red blood cells.
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