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Renal system physioex 8.0 exercise 9
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lcv123
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Glomerular Filtration
Activity 1:  Effect of Arteriole Diameter on Glomerular Filtration

1.   Compare this data with your baseline data.  How did increasing the afferent arteriole radius affect glomerular filtration rate?   
2.   Under these conditions, does the fluid flow through the nephron? 
3.   What is the glomerular filtration rate? 
4.   How does it compare to your baseline data, and why? 
5.   How did increasing the efferent radius affect glomerular filtration rate? If increased then Glomerular Filtration Rate would decrease
6.   How did decreasing the efferent radius affect glomerular filtration rate?  If increased then Glomerular Filtration Rate would decrease
7.   Physiologically, what could be the cause of a change in afferent or efferent arteriole radius? 

Activity 2:  Effect of Pressure on Glomerular Filtration

1.   As pressure increased, what happened to the pressure in the glomerulus? 
2.   What happened to the glomerular filtration rate? 
3.   How did the urine volume change? 
4.   How could increased urine volume be viewed as being beneficial to the body? 

Activity 3:  Combined Effects

1.   What happened to the glomerular filtration rate and urine volume after you reduced the pressure?  When the Valve was Closed, there was no Glomerular Filtration Rate and no Urine Production
2.   How could you adjust the afferent or efferent radius to compensate for the effect of the reduced pressure on glomerular filtration rate and urine volume?  Use the simulation to determine your answer. 
3.   What changes are seen in nephron function when the valve is closed? 
4.   Why were these changes seen? 
5.   Is the kidney functional when the glomerular filtration rate is zero?  Explain your answer. 
6.   What is the major “ingredient” that needs to be removed from the blood?
7.   Studies on aging have demonstrated that some nephrons may fail as we get older.  Will this be a problem regarding urine formation?
8.   If blood pressure went down – for example, as the result of blood loss – what changes would the kidney need to make to maintain its normal filtration rate? 

Simulating Urine Formation
Activity 4:  Effect of solute Gradient on Urine Concentration

1.   How did the urine solute concentration change as the concentration gradient of the interstitial fluid increased? 
2.   What happened to the urine volume as the concentration gradient increased?   Why? 
3.   By increasing the concentration gradient, what are you doing to the urine that is formed? 
4.   Predict what would happen to urine volume if you did not add ADH to the collecting duct. 

Activity 5:  Reabsorption of Glucose

1.   What happens to the glucose concentration as you add glucose carriers to the system? 
2.   At what point does the glucose concentration in the urine become zero? 
3.   What would you expect to find in the urine of a diabetic?  Why? 
 
Activity 6:  Effect of Hormones on Reabsorption

1.   Which hormone has the greater effect on urine volume?  Why? 
2.   How does the addition of aldosterone affect the concentration of potassium in the urine? 
3.   How does the addition of ADH affect the concentration of potassium in the urine? How does this compare to the effect of adding aldosterone, with respect to potassium concentration in the urine? 
4.   How does the addition of both hormones affect 1) urine concentration, 2) urine volume, and 3) potassium concentration? 
5.   If ADH were not used, how would the urine concentration vary?  Explain your answer. 

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Reply# 1
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Renal system physioex 8.0 exercise 9
Mar 31, 2011

I need help on this lab as well



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Reply# 2
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Renal system physioex 8.0 exercise 9
Mar 31, 2011

I need help on this lab as well

Which part?



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Renal system physioex 8.0 exercise 9
Mar 31, 2011

I need help on all of it as well..



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Renal system physioex 8.0 exercise 9
Apr 2, 2011

Which part?

Activity 6:  Effect of Hormones on Reabsorption if possible.



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Renal system physioex 8.0 exercise 9
Apr 2, 2011

and also Activity 3:  Combined Effects.



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Renal system physioex 8.0 exercise 9
Apr 3, 2011

I need help



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Renal system physioex 8.0 exercise 9
Apr 10, 2011

Activity 3

9. Record the glomerular filtration rate at a beaker pressure of 80 mm Hg: 129.61
13. Record the glomerular filtration rate at a beaker pressure of 85 mm Hg: 151.24
14. What variables other than beaker pressure could you change to return the glomerular filtration rate to “normal” (the value when beaker pressure is 80 mm Hg)? Circle the correct change in each set of parentheses: (decrease) in the afferent radius, (increase) in the efferent radius.
16. List the value of each variable that results in a glomerular filtration rate approximately the same as its starting value when beaker pressure is 85 mm Hg.
Afferent radius 0.53 mm
Efferent radius 0.46 mm

Hope this helps!



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Renal system physioex 8.0 exercise 9
Apr 10, 2011

Activity 6
5. Baseline urine volume: 201.00

6. Urine volume with aldosterone present: 180.90

In this run, how does the volume of urine differ from the previously measured baseline volume?
The volume is lower with aldosterone present than the base baseline urine volume.

Explain the difference in the total amount of potassium in the urine between this run and the baseline run.
There is more potassium in the run with aldosterone than the baseline run.

7. In this run, how does the volume of urine differ from the baseline measurement?
The volume with ADH is significantly lower than the baseline measurement.

Is there a difference in the total amount of potassium in this run and the total amount of potassium in the baseline run?
There is no difference in the amount of potassium in the urine.

Explain your answer. (Hint: The urine volume with ADH present is about one-tenth the urine volume when it is not present.)
Although the concentration is higher when ADH is present and the volume of urine has been reduced, the total amount of potassium has not changed.

Are the effects of aldosterone and ADH similar or antagonistic?
Similar—they both regulate sodium and water in the kidneys.

Consider this situation: we want to reabsorb sodium ions but do not want to increase the volume of the blood by reabsorbing water from the filtrate. Assuming that aldosterone and ADH are both present, how would you adjust the hormones to accomplish the task?
The amount of aldosterone would need to be increased while the amount of ADH would need to decrease.

Hope this helps too!



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Reply# 9
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Renal system physioex 8.0 exercise 9
Apr 19, 2011

Awesome response Grin



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Reply# 10
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Renal system physioex 8.0 exercise 9
Apr 19, 2011

Thanks! Smile



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Renal system physioex 8.0 exercise 9
Apr 26, 2011

Can anyone help me with the activities 4 and 5 of this exercise?



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Reply# 12
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Renal system physioex 8.0 exercise 9
Apr 26, 2011

I will tomorrow, I'm using another computer and all my files are on the other comp... Thumbs Down Make a new topic so that I don't forget.



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Renal system physioex 8.0 exercise 9
Apr 27, 2011

I actually figured it out, but thank you!



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