Discuss the experimental evidence that lead to the discovery of the receptor used by the leprosy bac

gmoney514

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8 years ago

Discuss the experimental evidence that lead to the discovery of the receptor used by the leprosy bac

1. Discuss the experimental evidence that lead to the discovery of the receptor used by the leprosy bacilli to bind to and invade Schwann cells. Also discuss what are the major effects of leprosy bacteria after it has entered the body and how leprosy change the properties of the Schwann cells and macrophages to promote its dissemination inside the host

2. What is induced pluripotent stem cells (IPS)? How are they generated and what can they be used for ? What are some therapeutic potential of the use of IPS?

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bio_man

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8 years ago

Quote from: gmoney514 (8 years ago)

2. What is induced pluripotent stem cells (IPS)? How are they generated and what can they be used for ? What are some therapeutic potential of the use of IPS?

Taking normal cells and using them to create pluripotent stem cells.

These can be used to generate human organ for transplantation.
Embryonic cord-blood cells were induced into pluripotent stem cells using plasmid DNA. Using cell surface endothelial/pericytic markers CD31 and CD146, researchers identified 'vascular progenitor', the high-quality, multipotent vascular stem cells. After the iPS cells were injected directly into the vitreous of the damaged retina of mice, the stem cells engrafted into the retina, grew and repaired the vascular vessels.
In 2014, type O red blood cells were synthesized at the Scottish National Blood Transfusion Service from iPSC. The cells were induced to become a mesoderm and then blood cells and then red blood cells. The final step was to make them eject their nuclei and mature properly. Type O can be transfused into all patients. Each pint of blood contains about two trillion red blood cells, while some 107 million blood donations are collected globally every year. Human transfusions were not expected to begin until 2016.

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bio_man

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8 years ago

Quote from: gmoney514 (8 years ago)

http://www.ppdictionary.com/bacteria/gpbac/leprae.htm

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