AGO2RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity.
http://www.jcancer.org/v06p0877.htmAg2OSilver oxide is the chemical compound with the formula Ag2O. It is a fine black or dark brown powder that is used to prepare other silver compounds.
Silver oxide can be prepared by combining aqueous solutions of silver nitrate and an alkali hydroxide. This reaction does not afford appreciable amounts of silver hydroxide due to the favorable energetics for the following reaction:
2 AgOH → Ag2O + H2O (pK = 2.875)
http://onlinelibrary.wiley.com/doi/10.1002/chem.201101032/abstract
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