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shayda.ma shayda.ma
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10 years ago
Contraction of a sarcomere, and thus contraction of the muscle as a whole, is accomplished by a cyclic sequence of interactions between actin (thin filaments) and myosin (thick filaments) in the sarcomere. Understanding this sequence of events is essential to understanding the mechanism of muscle contraction at the cellular and molecular levels.
Begin by considering a relaxed muscle. In this state, the myosin molecules of the thick filaments are not in contact with the actin of the thin filaments, and ADP and Pi are bound to the myosin heads. An action potential on the muscle cell plasma membrane initiates contraction of the sarcomeres from this relaxed state.

Drag the labels to their appropriate locations on the cycle diagram below.

Myosin binds ATP
Myosin head extends (pivots)
Myosin head pulls actin to the center of the sarcomere
Myosin releases P1
Myosin hydrolyzes ATP to ADP and P1
Myosin head forms a cross bridge with actin
Cross bridge between actin and myosin is broken.

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Post Merge: 10 years ago

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miaomiao23miaomiao23
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Posts: 1
10 years ago
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