1. A protein normally localized in the nucleus is now localized in the cytoplasm.
2. A protein acquires a DNA binding domain.
3. Tandem copies of a gene are found in the genome.
4. A copy of a bacterial gene is now found integrated on a human chromosome.
5. A protein becomes much more unstable.
6. A protein normally expressed only in the liver is now expressed in blood cells.
Types of genetic change:
A. mutation within a gene
B. gene duplication
C. mutation in a regulatory region
D. exon shuffling
E. horizontal gene transfer
