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Conformations of single-stranded nucleic acids

Description
Secondary and Tertiary Structure of Nucleic Acids

a) The random coil structure of denatured single strands. There is flexibility of rotation of residues and no specific structure.

b) Stacked-basostructure adapted by non–self-complementary single strands under “native” conditions. Bases stack to pull the chain into a helix, but there is no H-bonding.

c) Hairpin structures formed by self-complementary sequences; the chain folds back on itself to make a stem–loop structure.
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