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SlideshowReport

Intrinsic and extrinsic pathway

Description
Blood clotting involves a cascade of proteolytic activation of specific proteases, culminating in the transition of fibrinogen to fibrin.

Each factor (protease) in the pathway can exist in an inactive form (red) or an active form (green).

The cascade of proteolytic activations can start from exposure of blood at damaged tissue surfaces (intrinsic pathway) or from internal trauma to blood vessels (extrinsic pathway).

The common result is activation of fibrinogen to clotting fibrin.
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