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SlideshowReport

A peptide bond configurations, trans and cis (rotation around the CCO-N bond)

Description
A peptide bond exist in two possible configurations, trans and cis, which are related by rotation around the CCO-N bond.

The trans form is usually favored because in the cis configuration the R groups on adjacent -carbons can sterically interfere.

The major exception is the bond in the sequence X-Pro where X is any other amino acid. In this bond the cis configuration is sometimes allowed, although the trans configuration is still favored by about 4:1.
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