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SlideshowReport

The cross-linking reaction in peptidoglycan synthesis (left) and inhibition of the transpeptidase

Description
The cross-linking reaction in peptidoglycan synthesis (left) and inhibition of the transpeptidase enzyme, E, by penicillin (right):

Cross-links between adjacent peptidoglycan chains are formed by the action of a transpeptidase enzyme, as shown at the left.

At the right is shown how penicillin, a structural analog of the natural substrate, reacts with the active form of the enzyme to form an inactive covalent complex that resembles the enzyme–substrate complex.
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