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An example of genomic imprinting in the mouse.
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Tags
genomic, imprinting, mouse.
Description
In the cross on the left, a homozygous male with the normal Igf2 allele is crossed to a homozygous female carrying a defective allele, Igf2?. An offspring is phenotypically normal because the paternal allele is expressed. In the cross on the right, a homozygous male carrying the defective allele is crossed to a homozygous normal female. In this case, an offspring is dwarf because the paternal allele is defective and the maternal allele is not expressed.
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