(a) Increasing or decreasing the amounts of carbon dioxide or hydrogen ions (acid), or the temperature of the blood, shift the oxygen-hemoglobin dissociation curve. Actively metabolic tissues generate these products. By shifting the curve, different tissues obtain oxygen from hemoglobin in proportion to their metabolic needs. (b) Oxygen-hemoglobin dissociation curves for three mammals with low (elephant), moderate (human), or high (mouse) relative metabolic rates.
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