Hypofrontality in Schizophrenia

The images show composite functional MRI scans of subjects with schizophrenia and normal comparison subjects taken while the people were performing a task that required concentration and focused attention. The schizophrenic subjects show deficient activation of the dorsolateral prefrontal cortex (hypofrontality). (From MacDonald, A. W., Carter, C. S., Kerns, J. G., Ursu, S., Barch, D. M., Holmes, A. J., Stenger, V. A., and Cohen, J. D. American Journal of Psychiatry, 2005, 162, 475–484. Reprinted with permission from the American Journal of Psychiatry. Copyright © 2005 American Psychiatric Association.)