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SlideshowReport

PGC-1 and SIRT1 control the reprogramming of fuel utilization pathways in response to fasting

Description
A high NAD/NADH ratio, in response to low nutrients (fasting), activates SIRT1 to deacetylate PGC-1 upregulating its transcriptional coactivator function.

Tissue-specific transcriptional activation programs result in increased gluconeogenesis (liver) and increased fatty acid oxidation (skeletal and heart muscle).
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