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SlideshowReport

Schematic models of an IgG antibody molecule and an Fab fragment

Description
The IgG is made from two identical heavy chains and two identical light chains, all held together by disulfide bonds. Each chain contains both constant domains (C) and variable domains (V).

Constant domains are the same in all antibody molecules of a given class, whereas variable domains confer specificity to a given antigenic determinant.

Cleavage by certain proteolytic enzymes such as papain at the hinge and one Fc fragment regions allows production of two identical monovalent Fab fragments and one Fc fragment.
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