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SlideshowReport

Dipole interaction of E. coli enzyme structure

Description
A charge–dipole interaction stabilizes the phosphohistidine intermediate in the succinyl-CoA synthetase reaction.

In this schematic, based on the E. coli enzyme structure, the permanent dipoles of two -helices (the “power” helices) are oriented such that the d+ at their N-termini interact with the negative charges on the phosphate group of the active site N-phosphohistidine, stabilizing this transient reaction intermediate.
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