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Catalysis by the intervening sequence in Tetrahymena preribosomal RNA
Effect of cooperative substrate binding on enzyme kinetics
Nonprotein Biocatalysts: Catalytic Nucleic Acids
Description
a. Self-excision and splicing of the intervening sequence (IVS). Note that a pGOH is added in the reaction.

A series of further steps reduces the IVS to L-19 IVS.

b. Conversion of 2C5 to C4 + C6 by L-19 IVS.

This oligonucleotide can itself either shorten or elongate small oligonucleotides, acting here as a true ribozyme catalyst.
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