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Control points in pyrimidine synthesis

Description
The formation of N-carbamoyl-L-aspartate from carbamoyl phosphate and aspartate is the first committed step in a series of reactions that leads to synthesis of pyrimidine nucleotides, so control at or near this point is essential.

In prokaryotes, the aspartate carbamoyltransferase (ATCase) is regulated; in most eukaryotes, regulation is on the preceding step, catalyzed by carbamoyl phosphate synthetase II.
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