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The Regulation of Enzyme Activity: Allosteric Enzymes

Description
a. Quaternary structure of ATCase in the T state.

The enzyme has the six catalytic subunits (C) and six regulatory subunits (R).

Six catalytic sites lie in or near the grooves between the catalytic subunits.

Regulatory sites lie on the outer surfaces of the regulatory subunits.

b.  Transition of ATCase to the R state.

The transition involves a rotation of the regulatory subunits, which pushes the two tiers of catalytic subunits apart and rotates them slightly about the three-fold axis
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