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Knoop’s experiments to determine the b-oxidation of fatty acids

Description
When dogs fed fatty acids that had an even-numbered carbon chain, the final breakdown product, recovered from urine, was phenylacetic acid.

When the fed fatty acid had an odd-numbered chain, the product was benzoic acid.

These results led Knoop to propose that fatty acids are oxidized in a stepwise fashion, with initial attack on carbon 3 (the b-carbon with respect to the carboxyl group).

This attack would release the terminal two carbons, and the remainder of the fatty acid molecule could undergo another oxidation.
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