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SlideshowReport

Structure of a complex of a type II DNA methylase with DNA

Description
The structure is a ternary complex containing Hha methylase from Haemophilus haemolyticus, DNA, and S-adenosylhomocysteine.

The loops containing the catalytic site are in white, and the rest of the enzyme is in orange. S-Adenosylhomocysteine is in yellow, the DNA backbone is magenta, and bases are green.

In both views the flipped-out target cytosine base is clearly visible.

a. View looking down the helix.

b. Side view from the minor groove.
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