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The primase-polymerase switch during lagging strand synthesis
Action of a type I topoisomerase
Action of type I and type II topoisomerases, as shown by gel electrophoresis
Description
DnaB helicase encircles the lagging strand, and primase has synthesized an RNA primer.

Primase must contact SSB to remain bound.

Core polymerase on the lagging strand is forcing that strand and the daughter strand to loop out.

The c subunit of the complex interacts with SSB, leading to primase displacement.

The complex is opening the clamp, and a newly completed Okazaki fragment is being released, along with its template.

Primase rebinds to single-strand template DNA to begin a new primer.
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