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SlideshowReport

Simplified view of retrovirus life cycle

Description
The RNA genome contains long terminal repeats, to one of which a tRNA molecule binds.

Primer extension, partial RNA digestion, and circularization generate a substrate for extensive DNA synthesis.

Ultimately, a circular duplex DNA molecule is formed, and it is the likely substrate for integration into a host chromosome.

Evidence suggests that two viral RNA molecules must interact at step 2 or 3.
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