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SlideshowReport

A pathway for homologous recombination to repair DNA double-strand breaks

Description
a. MRN, aided by other proteins, trims ends, and the single-strand ends are coated with replication protein A, singlestrand binding protein.

b. RPA is replaced by Rad51(RecA counterpart), aided by the BRCA2 protein.

c. Strand invasion of the undamaged homologous chromosome is followed by DNA synthesis and cutting.

d. Which can yield either recombinant (right) or nonrecombinant left) chromosomes.
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