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SlideshowReport

A model for formation of a minimal preinitiation complex (PIC) for pol II on a TATA promoter

Description

In the simplest situation, binding of TATA-binding protein (TBP) initiates the sequence.

Alternatively, in vivo TFIID, which includes both TBP and associated factors (TAFs), is used.

This will also result in binding of TFIIA.

The series of dots indicates phosphorylation of the C-terminal domain (CTD) of Rpb1, the largest subunit of pol II.

Phosphorylation is necessary for release of the enzyme from the initiation site.
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