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Structure of the Dnmt3a heterotetramer complexed with a DNA 25-mer

Description
Although the two Dnmt3a active sites are not specifically shown in this model, they were reported to be about ten base pairs apart.

Binding of multiple methylase molecules along the DNA duplex could account for preferential methylation of a gene that contained CpG base pairs at 8- to 10-base pair spacings.
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