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Misfolding or refolding of some proteins can result in disease

Description
(a) The normal folding pattern for a prion protein. Most of the protein is in a helical configuration (red). (b) The protein has refolded to form a disease-causing prion. This refolding has altered the secondary and tertiary levels of protein structure. In this form, most of the protein is in pleated sheets (the yellow ribbon-like regions).
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