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Biology-Related Homework Help Cell Biology Topic started by: dank88 on Mar 18, 2014



Title: You have generated a knockout mouse that does not express CD40. Upon stimulation
Post by: dank88 on Mar 18, 2014
You have generated a knockout mouse that does not express CD40.  Upon stimulation with a T-dependent antigen, do you expect this mouse to be able to:

Secrete IgG antibodies specific for your antigen?


Secrete antigen-specific antibodies that have undergone class switching?


Thank you.


Title: Re: You have generated a knockout mouse that does not express CD40. Upon stimulation
Post by: padre on Mar 18, 2014
CD40 is a co-stimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on T=helper cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.


Title: Re: You have generated a knockout mouse that does not express CD40. Upon stimulation
Post by: dank88 on Mar 19, 2014
Thank you!


Title: Re: You have generated a knockout mouse that does not express CD40. Upon stimulation
Post by: padre on Mar 19, 2014
NP