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Title: T-cell receptors do not undergo isotype switching. Suggest a possible reason for this. What will ... Post by: QiTian on Jan 22, 2018 T-cell receptors do not undergo isotype switching. Suggest a possible reason for this.
What will be an ideal response? Title: T-cell receptors do not undergo isotype switching. Suggest a possible reason for this. What will ... Post by: omar.quesadamed on Jan 22, 2018 T-cell receptors are not made in a secreted form, and their constant regions do not contribute to T-cell effector function. Other molecules secreted by T cells are used for effector functions. There is therefore no need for isotype switching in T cells, and the T-cell receptor loci do not contain numerous alternative C genes.
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