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Title: What characteristic of Prader-Willi syndrome is not a characteristic of Angelman syndrome? Post by: goatMaster on Feb 12, 2018 What characteristic of Prader-Willi syndrome is not a characteristic of Angelman syndrome?
a. It is inherited from the father. b. Mental retardation is observable. c. Imprinting of an abnormal chromosome 15. d. Seizure disorder is present. Title: What characteristic of Prader-Willi syndrome is not a characteristic of Angelman syndrome? Post by: scott123 on Feb 12, 2018 ANS: A
A well-known disease example of imprinting is associated with a deletion of about 4 million base (Mb) pairs of the long arm of chromosome 15. When this deletion is inherited from the father, the child manifests Prader-Willi syndrome, whose features include short stature, hypotonia, small hands and feet, obesity, mild to moderate mental retardation, and hypogonadism. The same 4 Mb deletion, when inherited from the mother, causes Angelman syndrome, which is characterized by severe mental retardation, seizures, and an ataxic gait. |