Title: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 22, 2020 https://www.google.com/search?q=antiviral+agents+for+respiratory+diseases&tbm=isch&ved=2ahUKEwjvjMTWlq3oAhWT5TgGHQu2Ag8Q2-cCegQIABAC&oq=antiviral+agents+for+respiratory+diseases&gs_l=mobile-gws-wiz-img.12...0.0..375196...0.0..0.0.0.......0.iqDUGjxJ5FI&ei=e-B2Xq_jEJPL4-EPi-yKeA&bih=592&biw=360&prmd=insv
https://www.google.com/search?q=antiviral+agents+for+respiratory+diseases&tbm=isch&chips=q:antiviral+agents+for+respiratory+diseases,online_chips:viral+pneumonia&prmd=insv&hl=en&ved=2ahUKEwjaleX9pq3oAhXzD7cAHW7ZBkwQ4lYoAHoECAEQCw&biw=360&bih=592 This could be a good reference for manufacturing vaccines & cure /treatment drugs for COVID-19. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 22, 2020 Thanks. Attached image. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Mar 22, 2020 The same idea applies. Antiviral drugs work in two major ways, either they
1) they block the entry of the virus into the cell, or 2) prevent the drug from replicating once it has entered into the cell. All those outlined in the link fall into one of these categories, generally. Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 22, 2020 Thank you.
https://www.genengnews.com/news/coronavirus-treatment-could-lie-in-existing-drugs/ Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 22, 2020 Thanks.
https://www.genengnews.com/category/virology/coronavirus/ Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 22, 2020 Thanks.
https://www.medicalnewstoday.com/articles/coronavirus-existing-drugs-could-be-repurposed-to-treat-infection Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: duddy on Mar 22, 2020 The same idea applies. Antiviral drugs work in two major ways, either they 1) they block the entry of the virus into the cell, or 2) prevent the drug from replicating once it has entered into the cell. All those outlined in the link fall into one of these categories, generally. The general idea behind modern antiviral drug design is to identify viral proteins, or parts of proteins, that can be disabled. These "targets" should generally be as unlike any proteins or parts of proteins in humans as possible, to reduce the likelihood of side effects. The targets should also be common across many strains of a virus, or even among different species of virus in the same family, so a single drug will have broad effectiveness. For example, a researcher might target a critical enzyme synthesized by the virus, but not the patient, that is common across strains, and see what can be done to interfere with its operation. Once targets are identified, candidate drugs can be selected, either from drugs already known to have appropriate effects, or by actually designing the candidate at the molecular level with a computer-aided design program. Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 23, 2020 Thanks.
Reference : Pangolin https://www.nytimes.com/2020/02/10/science/pangolin-coronavirus.html Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 23, 2020 Thanks.
The Host carrier tracing of the COVID - 19 will be the key in manufacturing vaccine for the same. i.e. Pangolin, Bats ... Do you agree? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Mar 23, 2020 Thanks. Reference : Pangolin https://www.nytimes.com/2020/02/10/science/pangolin-coronavirus.html Thanks & Regards, Prashant S Akerkar When I look at this animal, I don't see it as something I'd be interested in eating, and definitely not by choice. I'm not even curious about how it tastes, at the end of the day it's probably no different than beef or pork. Not sure what the fascination is of the Chinese culture eating these animals, wish someone could explain it to me. Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Mar 23, 2020 The Host carrier tracing of the COVID - 19 will be the key in manufacturing vaccine for the same. i.e. Pangolin, Bats ... Do you agree? No, not true. We, too, are hosts. Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 26, 2020 Thanks.
Vaccines updates news for COVID-19. Dr Anthony Fauci https://m.facebook.com/story.php?story_fbid=624068521715499&id=5550296508 Prof Ian Fraser https://m.facebook.com/story.php?story_fbid=3208264875887994&id=107637365950776 Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Mar 26, 2020 Quote https://m.facebook.com/story.php?story_fbid=624068521715499&id=5550296508 Conceptually it isn't difficult, conceptually. In other words, theoretically the science behind it is simple if you understand the basics of biology. However, we don't know the impact it will have on the recipient 3 months, 6 months, a year from now. Quote https://m.facebook.com/story.php?story_fbid=3208264875887994&id=107637365950776 Thanks for sharing, interesting take by a world-renowned medical doctor Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 28, 2020 Thanks.
https://news.utexas.edu/2020/02/19/breakthrough-in-coronavirus-research-results-in-new-map-to-support-vaccine-design/ Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 28, 2020 Thanks.
https://m.box.com/shared_item/https%3A%2F%2Futexas.box.com%2Fs%2Fwbmj6r6z2wppn4ue7b1qgkjsjx2nxubr/view/619416289158 Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 28, 2020 Thanks. Jason Mclellan Labs research on COVID-19 vaccine. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 29, 2020 Thanks.
Jason Labs are doing good work in designing & developing a COVID-19 vaccine. References: Comparing Genome sequences. https://en.wikipedia.org/wiki/Comparative_genomics https://www.google.com/search?q=comparing+genome+sequences&oq=comparing+genom&aqs=chrome.2.69i57j0l3.7050j1j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8 What's your opinion? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 29, 2020 Thanks.
Attached Reference. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Mar 29, 2020 Thanks. Modern drugs & vaccine design & development abstract using comparative genomics. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Mar 29, 2020 Comparative genomics is used to compare genomic features between different or similar organisms. It allows us to understand how the virus' genome changes from one recipient to the other, helping to predict how quickly it mutates and which parts of the species is most prone to mutation. We've already used it to identify the possible origins of the virus, where the one harvested from humans and that found natively in bats share a 99% similar genome. We will be using it forward to make future vaccines if the spread were to continue, much the same way the flu mutates every year.
Thanks for sharing these excellent resources, this document was particular informative: annurev-virology-110615-042301.pdf Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 2, 2020 Thanks.
https://covid19vaccinetrial.co.uk/home https://www.facebook.com/jennerinstitute/ Are you optimistic regarding this vaccine research? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 2, 2020 Thanks.
https://www.google.com/search?q=jenner+institute+oxford&oq=&aqs=chrome.0.35i39l4j69i177.-1j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8 https://en.wikipedia.org/wiki/Edward_Jenner_Institute_for_Vaccine_Research https://www.ndm.ox.ac.uk/the-jenner-institute Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 2, 2020 Thanks.
ChAdOx1 https://www.google.com/search?q=ChAdOx1&oq=ChAdOx1+&aqs=chrome..69i57.18441j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8 This looks a promising vaccine. What's your opinion? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 2, 2020 Thanks.
https://www.google.com/search?tbm=isch&sxsrf=ALeKk013U4e9jef0yGYCdUyRWpIDKa31Hg%3A1585849685018&source=hp&ei=VCWGXo-rPJWvyAPUyYlw&q=ChAdOx1 Your opinion regarding ChAdOx1. This looks promising? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 2, 2020 Thanks. https://covid19vaccinetrial.co.uk/home https://www.facebook.com/jennerinstitute/ Are you optimistic regarding this vaccine research? Thanks & Regards, Prashant S Akerkar Not by this organization. I don't think they have the best leadership. ChAdOx1 is a vaccine adenovirus vector that could be used to deliver vaccine antigens where strong cellular immune responses are required. I don't see a problem using this, and it looks like they're moving forward with it: The ChAdOx1 MERS vaccine consists of the replication-deficient simian adenovirus vector ChAdOx1, containing the MERS Spike protein antigen. https://ichgcp.net/clinical-trials-registry/NCT03399578 Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 2, 2020 Thanks.
https://en.wikipedia.org/wiki/Sarah_Gilbert_(scientist) https://www.theguardian.com/society/2020/mar/19/uk-drive-develop-coronavirus-vaccine-science https://en.wikipedia.org/wiki/Adenoviridae Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 2, 2020 I just don't think her team will rise to the top on this one
Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 3, 2020 Thanks.
https://www.jenner.ac.uk/ We should be optimistic. Isn' it? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 3, 2020 Of course, but it's more important to be realistic with the timeline. As per their website:
Vaccine development during an epidemic: Experts have estimated that it will take 12-18 months to develop a new vaccine at high speed. Under normal circumstances, most vaccine development programmes take more than five years, so this is still a considerably accelerated timescale. So while everyone is working diligently towards a common goal, to ensure safety and health risk management issues are properly addressed, time needs to be taken to do things right. Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 5, 2020 https://www.linkedin.com/mwlite/company/curevac
https://www.google.com/search?q=franz+werner+haas&oq=&aqs=chrome.1.35i39l3j46j69i177.-1j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8 https://www.google.com/search?client=ms-android-lava&sxsrf=ALeKk03tz2HNNpAbkihB9gcpk0WvKNlSmg%3A1586069020398&ei=HH6JXvHEF4vC3LUPv_if8AM&q=franz+werner+haas+on+COVID-19+vaccine+development&oq=franz+werner+haas+on+COVID-19+vaccine+development&gs_lcp=ChNtb2JpbGUtZ3dzLXdpei1zZXJwEAw6BggAEBYQHjoFCCEQoAFQ0hJYuoEBYJWJAWgAcAB4BIAB4wWIAYQ8kgEOMC4xNy4xLjAuMi4zLjOYAQCgAQE&sclient=mobile-gws-wiz-serp https://www.curevac.com/contact-us# Curevac GmbH pharma co is also working on COVID-19 vaccine. We can get the latest updates from them regarding the COVID-19 vaccine development stage by sending emails? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 5, 2020 Thanks.
Latest updates regarding COVID-19 vaccine development. info@curevac.com communications@curevac.com Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 5, 2020 We can get the latest updates from them regarding the COVID-19 vaccine development stage by sending emails? For each milestone, they should publish an article on their findings. You could email them, but I'd wait for a major breakthrough. Quote info@curevac.com communications@curevac.com You're most likely to get an auto response, but I'm curious to see how they'd respond. I'd guess they only respond to journals or prominents members of health departments around the world. Give it a try, report back to us! Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 5, 2020 Thanks.
Curevac has published news in New York Times on 4th April regarding COVID-19 vaccine. https://www.nytimes.com/2020/04/01/podcasts/the-daily/coronavirus-vaccine.html Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 5, 2020 Curevac has published news in New York Times on 4th April regarding COVID-19 vaccine. What's the take-home message of this update? Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 5, 2020 Thanks.
The news do not highlight the current development progress in % completion of COVID-19 vaccine from Curevac biotech co. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 6, 2020 Thanks.
Vaccines development from different Biopharma cos. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 6, 2020 ^^ Interesting document. Where did you unearth this thing?
The news do not highlight the current development progress in % completion of COVID-19 vaccine from Curevac biotech co. From my experiencing working in a lab, experiments take time to conduct - weeks, months, and years. Having a journalist probe the researchers every other day certainly won't make them work any faster. Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 8, 2020 Thank you.
https://www.indiatoday.in/science/story/coronavirus-all-you-need-to-know-about-hydroxychloroquine-and-covid-19-treatment-1664263-2020-04-07 Your views, opinion regarding Hydroxychloroquine as a effective drug in COVID-19 treatment? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 8, 2020 Thanks.
https://en.wikipedia.org/wiki/Hydroxychloroquine https://www.google.com/search?q=hydroxychloroquine+covid+19&oq=&aqs=chrome.1.35i39l4j69i177.-1j0j7&client=ms-android-lava&sourceid=chrome-mobile&ie=UTF-8 https://www.google.com/search?q=hydroxychloroquine&client=ms-android-lava&prmd=nibv&sxsrf=ALeKk02Az1DMpo0ZpmCY1FMHsyN65pQswg:1586332556388&source=lnms&tbm=isch&sa=X&ved=2ahUKEwirmpOkrdjoAhWJUn0KHXr2BaQQ_AUoAnoECBQQAg&biw=360&bih=592 Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 8, 2020 Thank you.
The Hydroxychloroquine drug evaluation success will depend upon getting the latest data for COVID-19 patients cured with Hydroxychloroquine and without any other complications or side effects across the globe? Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 8, 2020 Hydroxychloroquine works by slowing the rate at which a virus reproduces itself. This buys time for a person's immune system to build up its own defenses to take on the coronavirus.
Using a hydroxychloroquine-azithromycin cocktail appear to have helped people recover faster and avoid the most severe symptoms of COVID-19. I'm not sure how azithromycin helps - as far as I know, it is an antibiotic. I have no idea of the mechanism involved, and how it relates to viral reproduction. At the moment the extent which azithromycin could have a benefit in treating viruses and the mechanisms behind it aren’t well understood. Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 8, 2020 Thanks.
https://m.youtube.com/watch?v=keFNYV0NaxE Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 8, 2020 Thanks.
https://m.youtube.com/watch?v=8J-06J22oj8 Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Apr 9, 2020 Thanks.
Curevac AG replied to my email giving information that they now have created a dedicated webpage for latest updates on COVID-19 vaccine development. https://www.curevac.com/covid-19 Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on Apr 9, 2020 Thanks for the update
Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Dec 30, 2020 Thanks.
https://www.indiatoday.in/coronavirus-outbreak/vaccine-updates/story/uk-regulator-approves-oxford-astrazeneca-coronavirus-vaccine-paves-way-for-rapid-rollout-1754466-2020-12-30 News Updates regarding COVID-19 vaccine development. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: gpenn123 on Dec 30, 2020 Not sure if the effectiveness of this one is as good as the other two by Pfizer or Moderna.
Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on Jan 3, 2021 Thanks.
News updates regarding COVID-19 vaccine in India. https://www.indiatoday.in/news-analysis/story/why-covaxin-covishield-best-option-for-india-against-covid19-pandemic-1755517-2021-01-03 Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on May 15, 2021 Thanks.
Currently Covishield and Covaxin COVID vaccines are administered in our country. The third COVID vaccine from Sputnik, Russia import is in pipeline. https://indianexpress.com/article/india/sputnik-vaccine-covid-vaccines-coronavirus-cases-7315642/ Thanks. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on May 15, 2021 Which one are Indians mostly gravitating toward, the American or Russian vaccine?
Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on May 18, 2021 Thanks.
https://www.businesstoday.in/coronavirus/apart-serum-bharat-biotech-5-vaccine-makers-india-hope-against-covid-19/story/439231.html Apart from Covishield, Covaxin & Sputnik COVID vaccines, other pharma cos are being evaluated for the same to meet the requirements. Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: bio_man on May 18, 2021 Is Covishield an Indian-invented or Indian-manufactured vaccine?
Title: Re: Antiviral agents for respiratory diseases. Post by: prashantakerkar on May 18, 2021 Thanks.
https://www.seruminstitute.com/product_covishield.php Thanks & Regards, Prashant S Akerkar Title: Re: Antiviral agents for respiratory diseases. Post by: jennifergillman on Sep 11, 2022 Not sure if the effectiveness of this one is as good as the other two by Pfizer or Moderna. Nevertheless, as I understand it, there is an effect |