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Biology-Related Homework Help Biochemistry Topic started by: science toolbar on Apr 23, 2020



Title: What is your considerations regarding the research below ? (HUVECs and C.E vs RMF)
Post by: science toolbar on Apr 23, 2020
Hello !

I need some considerations regarding the research below :

" Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914427/

Thx,

ST






Title: Re: What is your considerations regarding the research below ? (HUVECs and C.E vs RMF)
Post by: bio_man on Apr 23, 2020
I'll highlight some keep excerpts:

In this study, we aimed to verify the function of the Ca2+ channel in the endoplasmic reticulum as a magnetic field-induced receptor. Combining physics with biology, the results of our study are very important in highlighting a range of MF applications in the future.

In addition, we found that the effect of RMF exposure on inhibition of aging depends on frequency, intensity, and duration of action. Sensitivity to the induced magnetic field and/or current in the animal changes during aging.

in this study, we found that the RMF acts directly act on the calcium channel of the endoplasmic reticulum, possibly due to the greater influence of the RMF compared with the SMF, which amplifies the effect of the magnetic field.

RMF significantly increased the resistance of nematodes to adverse conditions such as heat stress and effectively reduced ROS levels, indicating that RMF promoted longevity. We also found that RMF exposure reduced the ATP level of the entire nematode, which was consistent with the effects observed in HUVECs.

Furthermore, we observed that RMF significantly upregulated the expression of the stress genes sir2.1, ctl-1, hsp-16.1, hsp-16.2 and gcs-1. S

So many things happening in this study. I don't understand why the researchers focused on TWO completely different types of cells. I think they should have started with C. elegans, then used the same procedure with the endothelial human cells in another study. Reading this study is like eating a salad. Every paragraph explains something different. I find what they wrote about the nematode to be more promising in the grand scheme of things that what they found regarding the HUVEC.


Title: Re: What is your considerations regarding the research below ? (HUVECs and C.E vs RMF)
Post by: science toolbar on Apr 24, 2020
thx ST ,