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Title: Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. H Post by: BreakFree on Feb 8, 2015 Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. How is this possible?
1. Fluoroquinolones that are effective against gram-negative organisms block the enzyme topoisomerase IV, which stops the migration process of the two new strands to opposite sides of the cell. 2. Fluoroquinolones that are effective against gram-positive organisms block the enzyme DNA gyrase, which stops relaxation of the supercoil of the DNA. 3. Fluoroquinolones that are effective against gram-negative organisms block the enzyme DNA gyrase, and those effective against gram-positive organisms block topoisomerase IV. 4. All fluoroquinolones are effective against both gram-negative and gram-positive organisms. There is no difference in the way they block bacterial DNA replication. Title: Re: Fluoroquinolones are known to be effective against both gram-negative and gram-positive organism Post by: ngin on Feb 11, 2015 Content hidden
Title: Re: Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. H Post by: BreakFree on Feb 15, 2015 Sounds and feels right, thank you for the rationale.
Title: Re: Fluoroquinolones are known to be effective against both gram-negative and gram-positive organisms. H Post by: ngin on Feb 16, 2015 I've studied this stuff recently, so I knew what the answer was. Good luck with the rest.
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