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Title: Is Sevenless an EGFR? Post by: CooperS on Mar 13, 2015 Hi,
Is Sevenless considered an EGFR? Sevenless does not dimerize, right? Do EGFR's dimerize by definition? Thanks Title: Re: Is Sevenless an EGFR? Post by: rsb on Mar 14, 2015 The sevenless gene encodes a receptor tyrosine kinase (RTK).
Title: Re: Is Sevenless an EGFR? Post by: CooperS on Mar 14, 2015 The sevenless gene encodes a receptor tyrosine kinase (RTK). Yes, but aren't EGFR's RTK's? The two categories aren't mutually exclusive. I am not sure if BoSS is considered a "growth factor" or not. Title: Re: Is Sevenless an EGFR? Post by: bio_man on Mar 14, 2015 Yes, but aren't EGFR's RTK's? Hi Cooper, according to Wikipedia, the epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Not entirely sure what that means. I think I may need to touch up on this, I also found this which I found interesting: The R8 photo receptor contains an activator of the RTK (receptor tyrosine kinase) for on a precursor R7 cell, called the bride of sevenless (BOSS). The binding of BOSS to sevenless stimulates a complex series of reactions involving the RTK (sevenless), MAP kinases, Ras and many more molecules to differentiate that precursor R7 photo receptor to a fully functional R7 photo receptor that can see UV light. |