|
Title: Briefly describe positive and negative selection of T cells in the thymus. Post by: tapey1996 on Oct 1, 2015 Briefly describe positive and negative selection of T cells in the thymus.
Title: Re: Briefly describe positive and negative selection of T cells in the thymus. Post by: Mallyboo on Oct 2, 2015 Positive selection selects for those T cells that react with MHC: self antigen. Negative selection eliminates those that react strongly with MHC: self antigen. Thus, successful T cell differentiation selects for MHC restricted TCR's with low affinity for self antigens. Cells that fall outside this range, primarily die via apoptosis. The rationale here is that a T cell that binds weakly to self MHC/self Antigen will not be activated but will be activated by a stronger binding to self MHC/ foreign Antigen complex
|