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Title: What is the difference between Pluripotent stem cells, totipotent stem cells and multipotent stem cells? ? Post by: juliaroberts on Oct 3, 2012 What is the difference between Pluripotent stem cells, totipotent stem cells and multipotent stem cells? ?
Title: What is the difference between Pluripotent stem cells, totipotent stem cells and multipotent stem cells? ? Post by: Firedancer20 on Oct 3, 2012 The zygote is totipotent, capably of growth and differentiation into all cell types to produce an organism. Once differentiation begins the regulation results in pluripotent progenitors only capable of producing specific cell lineages.
Each tissue type has a pattern of genes, expressed in a regulated fashion, that is a subset of the whole genome. Regulation increases in daughter cells as tissue and later organ systems develop. Regulation increasingly blocks expression of inappropriate genes, it down regulates genes so cells eventually become multipotent or specialized stem cells that are retained throughout adult life. These can divide to produce organ specific cell types for the normal function of replacement and repair. |