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Title: The DNA in a human chromosome is about 10cm in length. A typical human cell has a diameter of ... Post by: mkzb on Nov 19, 2016 The DNA in a human chromosome is about 10cm in length. A typical human cell has a diameter of 15µm, and its nucleus occupies 30% of the cell volume. What is the minimum number of times the DNA in this human chromosome must be folded to fit within the cell?
Title: Re: The DNA in a human chromosome is about 10cm in length. A typical human cell has a diameter of ... Post by: psyche360 on Nov 20, 2016 Chromosomal DNA is highly organized in an interphase chromosome. It is more than just a question of folding it into the available space. The DNA is wrapped around histones. The histones associate into higher-order structures. It is also now known that there are specific interactions of chromosomal locations. See this paper, for example:
https://www.researchgate.net/deref/http%3A%2F%2Fwww.nature.com%2Farticles%2Fncomms7178 Title: Re: The DNA in a human chromosome is about 10cm in length. A typical human cell has a diameter of ... Post by: psyche360 on Nov 20, 2016 You can measure DNA length using an atomic force microscope.
The first step of packing is realized by the winding of DNA around a protein core. Next phase is the coiling of beads in a helical structure called the 30 nm fiber. https://www.researchgate.net/deref/http%3A%2F%2Fwww.ndsu.edu%2Fpubweb%2F~mcclean%2Fplsc431%2Feukarychrom%2Feukaryo3.htm |