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Title: How nucleosomes are positioned Post by: lrob on Nov 22, 2011 Hey guys!
I'm starting quite an interesting literature project on whether/how nucleosomes are positioned in the genome. It's fairly open-ended and meant to test research skills on an emerging topic. The main questions I will try to answer on this subject will be: ------------------------------------ How are nucleosomes positioned and organised in the genomes of different species? (Comparison between organisms) Is positioning information an intrinsic part of DNA, is it governed by the histone interaction, is it mediated by the cell environment- or a combination of all of these? What defects and diseases are related to nucleosome positioning defects? ------------------------------------- These I think are good questions to answer to make an interesting an informative report. However if anyone has any other areas they think would be interesting to research into, any ideas would be very welcome. It's a pretty cool subject, and for those who aren't familiar with this topic Jiang and Pugh have an excellent introductory review. http://www.nature.com/nrg/journal/v10/n3/full/nrg2522.html (http://www.nature.com/nrg/journal/v10/n3/full/nrg2522.html) Thanks! :) Title: Re: How nucleosomes are positioned Post by: bio_man on Nov 22, 2011 It is, but in what format are you writing this?
Title: Re: How nucleosomes are positioned Post by: lrob on Nov 22, 2011 I'm doing a critical analysis of papers researching into the questions I've decided to look into. For example I would look at papers researching into whether histone binding is governed by intrinsic information in DNA, comparing methods and results and coming to my own conclusion.
Title: Re: How nucleosomes are positioned Post by: bio_man on Nov 22, 2011 I'm doing a critical analysis of papers researching into the questions I've decided to look into. For example I would look at papers researching into whether histone binding is governed by intrinsic information in DNA, comparing methods and results and coming to my own conclusion. Kind of like a review, correct? In that case, it all depends on how much you have to write about. Are there any guidelines when it comes to the word limit? Title: Re: How nucleosomes are positioned Post by: lrob on Nov 28, 2011 Sorry for the late reply, yes a sort of review- the word count is quite generous, it's 10,000 words, so plenty of room for new ideas! Thanks!
Title: Re: How nucleosomes are positioned Post by: duddy on Nov 28, 2011 |