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Title: The table shown lists the approximate new mutation rates for three autosomal dominant human diseases Post by: davingi18 on Mar 24, 2014 The table shown lists the approximate new mutation rates for three autosomal dominant human diseases.
Trait Mutations per 106 gametes Retinoblastoma (tumor of the retina) 20 Achondroplasia (statural dwarfism) 80 Neurofibromatosis (tumor of nervous tissue) 220 In a series of 50000 consecutive live births recorded in a large metropolitan area, how many new cases of each disease are expected? Title: The table shown lists the approximate new mutation rates for three autosomal dominant human diseases Post by: confuzed on Nov 15, 2014 Has anyone figured this one out yet?
Title: Re: The table shown lists the approximate new mutation rates for three autosomal dominant human dise Post by: bio_man on Nov 15, 2014 Guessing that you can divide 20 by 106 = 0.1886.
0.1886 * 50000 = 9434 where born with this condition. This is my guess... Title: Re: The table shown lists the approximate new mutation rates for three autosomal dominant human dise Post by: pennan on Nov 26, 2014 Question:
Retinoblastoma = 20 mutations per 10^6 gametes Achondroplasia = 80 mutations per 10^6 gametes Neurofibromatosis = 220 mutations per 10^6 gametes In a series of 50000 consecutive live births recorded in a large metropolitan area, how many new cases of each disease are expected? ----------------------------------------------------------------------------- Answer: Retinoblastoma = 2 Achondroplasia = 8 Neurofibromatosis = 22 ----------------------------------------------------------------------------- Explanation: Divide the rate of each mutation by (10^6); and multiply by 50,000. For example, Retinoblastoma has 20 mutations per 10^6 gametes. 20 / (10^6) = 2.00E^-5. 2.00E^-5 x 50,000 = 1. Doing the same for Achondroplasia, you will get 4; doing the same for Neurofibromatosis will get you 11. This is the rate of mutations per parent. However, this question asks about "live births", and a live birth would require two gametes (one from each parent). Thus, each number (1, 4, and 11) must be multiplied by two: 1 x 2 = 2 4 x 2 = 8 11 x 2 = 22 Hope this helps! Title: Re: The table shown lists the approximate new mutation rates for three autosomal dominant human dise Post by: zola munifa on Dec 1, 2014 thank you so much!
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