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Title: The molecule 1,3-bisphosphoglycerate can be converted to 3-phosphoenolpyruvate t Post by: mikael on Apr 8, 2014 The molecule 1,3-bisphosphoglycerate can be converted to 3-phosphoenolpyruvate two ways. One way is catalyzed by the glycolytic pathway enzyme phosphoglycerate kinase. The other route is a two step reaction sequence that uses the enzymes bisphosphoglycerate mutase and 2,3-bisphosphoglycerate phosphatase. The intermediate product of the two-step sequence is 2,3-BPG which is an allosteric inhibitor of hemoglobin. What disadvantage would there be if the glycolytic pathway only used the two-step reaction sequence?
A) The step catalyzed by phosphoglycerate kinase is one of the ATP producing steps of glycolysis. Using only the two-step reaction sequence would reduce the number of ATP's produced. B) There is no disadvantage to the two-step sequence other than having to use more than one enzyme. C) The molecule 2,3-BPG is also a potent inhibitor of PFK-1. Even transient production of 2,3-BPG will significantly slow glycolysis. D) Too much 2,3-BPG would be produced which would cause clumping of red blood cells. Title: Re: The molecule 1,3-bisphosphoglycerate can be converted to 3-phosphoenolpyruvate t Post by: padre on Apr 14, 2014 Content hidden
Title: Re: The molecule 1,3-bisphosphoglycerate can be converted to 3-phosphoenolpyruvate t Post by: mikael on Apr 14, 2014 Thanks Padre
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