|
Title: Determine the effect of each mutation on the length of the protein. Post by: dexterm00 on Apr 13, 2014 Mutations in the IL2RG gene cause approximately 30 percent of severe combined immunodeficiency disorder (SCID) cases. These mutations result in alterations to a protein component of cytokine receptors that are essential for proper development of the immune system.
The IL2RG gene is composed of eight exons and contains upstream and downstream sequences that are necessary for proper transcription and translation. Below are some of the mutations observed. For each, determine its likely influence on the IL2RG gene product (assume its length to be 375 amino acids). Determine the effect of each mutation on the length of the protein. nonsense mutation insertion in Exon 1, frameshift insertion in Exon 7, frameshift missense mutation deletion in Exon 2, frameshift deletion in Exon 2, in frame deletions of Exon 2 and 3 Sort the mutations into the appropriate: short protein longer protein same size protein cannot be determined Title: Re: Determine the effect of each mutation on the length of the protein. Post by: duddy on Apr 18, 2014 Hi dexterm00, could you give us an update on what you did here?
Title: Re: Determine the effect of each mutation on the length of the protein. Post by: tgb0077 on Nov 12, 2014 Content hidden
Title: Re: Determine the effect of each mutation on the length of the protein. Post by: candyh on Nov 14, 2014 Thank you
Title: Re: Determine the effect of each mutation on the length of the protein. Post by: emthomas201 on Nov 20, 2014 thanks
Title: Re: Determine the effect of each mutation on the length of the protein. Post by: adeno22 on Nov 22, 2014 what is it? It won't let me see...
Title: Re: Determine the effect of each mutation on the length of the protein. Post by: duddy on Nov 23, 2014 |