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Title: Why GP120 and GP41 proteins are not detectible by immune system? Post by: Astacus on Aug 29, 2014 Why GP120 and GP41 proteins are not detectible by immune system?
These two are viral (HIV) proteins attached to host mebrane. Why immune system dosent react to them? Title: Re: Why GP120 and GP41 proteins are not detectible by immune system? Post by: skip5284 on Aug 29, 2014 Why GP120 and GP41 proteins are not detectible by immune system? They are detectable. Where did you get that idea from? Title: Re: Why GP120 and GP41 proteins are not detectible by immune system? Post by: Astacus on Aug 29, 2014 Well, then why our innune system dosent and get rid of HIV with antibodies?
Title: Re: Why GP120 and GP41 proteins are not detectible by immune system? Post by: bio_man on Aug 29, 2014 Watch this, explains it well...
https://www.youtube.com/watch?v=hdgNnXLY8LU Title: Re: Why GP120 and GP41 proteins are not detectible by immune system? Post by: Astacus on Aug 29, 2014 I know the HIV cycle and video dosent aswer my question... If GP120 and GP41 are viral proteins they should be detected by immune system and in some time there should be alot of antibodies against them in host blood. Next step should be opsonisation and getting rid of virus.
Title: Re: Why GP120 and GP41 proteins are not detectible by immune system? Post by: bio_man on Aug 29, 2014 To check if someone is infected with the virus, I believe artificial GP120 and GP41 antigens are used. If these antigens react with antibodies found in the blood of an infected person, coagulation takes place, and this means the person has been previously infected with the virus. This suggests that the immune system detects HIV, but the mechanism of action of HIV, binding to CD4 T cells, then integrating its genome into the host, cannot be controlled.
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